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Gene Mutation Tied to Autism


Sept. 6, 2007 — Researchers today reported that they’ve found a other way to study a quality transformation connected to autism.

The researchers report that they have hereditarily designed mice with a genetic mutation seen in some individuals with autism spectrum disorders.

The change involves a portion of a quality that creates a protein called neuroligin-3, which makes a difference nerve cells communicate with each other.

The analysts found that mice with the neuroligin-3 gene transformation were less social than mice without that change. The mutated mice were too speedier at exploring a watery maze.

Clearly, mice are very different from people. But the mutated mice “may be a valuable model for studying autism-related behaviors,” type in Thomas Sudhof, MD, and colleagues in today’s edition of Science Express.

Sudhof, a molecular genetics teacher at the College of Texas Southwestern Restorative Center at Dallas, notes that the mice didn’t have auxiliary problems in the brain.

“What sets this mouse demonstrate apart is that the mouse appears profoundly particular social shortages and memory improvement, but as far as ready to tell, no other pathologies. This makes it a possibly useful show for a subset of individuals with extreme introvertedness range disarranges with fair such characteristics,” Sudhof states in a news release.

Sudhof’s team isn’t contending that the change they considered is solely capable for autism.

In reality, other autism gene researchers have suggested that autism may be influenced by 100 or more different genes.

In spite of the fact that researchers haven’t pinned down all of the genetic or environmental influences on extreme introvertedness, they may have a other way to think about autism in lab mice, Sudholf’s think about appears.

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