Feb. 25, 2008 — Scientists may be one step closer to creating a blood test for bipolar disorder and other mood disorders.
Temperament disarranges may have blood biomarkers — chemicals in blood — that can be recognized, modern investigate shows.
In a preliminary study, analysts distinguished 10 biomarkers in blood samples from adults with bipolar disorder.
Those biomarkers “may offer an out of the blue instructive window into brain working and disease state,” compose the analysts, who included A.B. Niculescu III, MD, PhD, partner teacher of psychiatry, restorative neurobiology, and neuroscience at Indiana University’s medical school.
To begin with, 29 bipolar patients provided blood samples and rated their mood. Mood appraisals were high for 13 patients, low for 13 other patients, and middle for the final three patients.
By analyzing those blood samples, the researchers came up with a list of genes that were more or less active in patients with high and low moods.
Next, the researchers winnowed down the quality list, based on lab tests in mice and brain tissue from people who had died with bipolar disorder, depression, and other temperament disorders.
Based on all that work, the researchers recognized 10 biomarkers — five linked to high mood and five tied to moo temperament — in bipolar patients.
Finally, Niculescu’s team measured those biomarkers in 19 other bipolar patients and 30 patients with maniacal clutters. The biomarkers weren’t culminate at identifying patients with high and low temperament, but they were right 60% to 70% of the time.
The ponder shows up in the journal Atomic Psychiatry.